Don's Home Health Corona Virus Variants Contact
last updated 25 June 2024

Viruses like SARS-CoV-2 continuously evolve as changes in the genetic code (caused by genetic mutations or viral recombination) occur during replication of the genome.

In late 2023, the World Health Organization listed nine variants as circulating at the time. More than 50 variants have been identified; although some are no longer spreading. COVID Variants | WebMD

Some variants have different behaviors.
For example Omicron BA.2 infects different cells in the upper respiratory tract rather than in the lungs, which makes it more transmissible but less severe than the previous variants.
The death rates were slightly lower even though the infection rates 4 or more times higher, so the death per infection were about ¼ the rate of previous variants.
Delta caused more severe disease than other variants in people who weren't vaccinated.

The World Health Origination (WHO) and The European Centre for Disease Prevention and Control (ECDC) classify some variants with concerning properties likely to impact the epidemiological situation in the European Union (EU) and European Economic Area (EEA) as variant under monitoring (VUM), variant of interest (VOI) and variant of concern (VOC).
XBB.1.5-like (Omicron) and BA.2.86 (omicron) are classified as VOI in May, 2024.
Other variants have been de-escalated e.g. ALpha (B.1.1.7), Delta (B.1.617.2), Omicron (BA.1,BA.3, BA.2.L452x)

SARS-CoV-2 variants of concern as of 31 May 2024 | ECDC




SARS-CoV-2 Variant Classifications and Definitions





New variants emerge in different places.

SARS-CoV-2 Variant Classifications and Definitions


A Timeline of COVID-19 Variants | VeryWellHealth

From Alpha to Omicron: How Different Variants of Concern of the SARS-Coronavirus-2 Impacted the World | PubMed - NIH


Viral tropism refers to the capability of an infectious virus to infect particular cells (cellular tropism), tissue (tissue tropism) or host species (host tropism). Omicron (B.1.1.5, BA, XBB, JN, KP, ...) had altered cell tropism (the ability of a virus to infect a given cell type or tissue) compared with previous (B.1.6...) Variant ofs Concern (VOC)s, favoring infection of the upper respiratory tract.
That resulted in a much higher infection rate, but lower hospitalizations and deaths because of reduced severity.


SARS-CoV-2 Omicron variants: burden of disease, impact on vaccine effectiveness and need for variant-adapted vaccines


Links:
SARS-CoV-2 Variant Classifications and Definitions | CDC Nextstrain SARS-CoV-2 resources Overview of Variants/Mutations
SARS-CoV-2 variants of concern as of 31 May 2024 | ECDC